Currently we use one to control an AV receiver, digital box and projector. Personally i think this is the best one i've used.
Although initially to set up takes a bit of time (you have to load a program onto a computer and then add devices to the remote using the provided usb cable), the time it saves in day to day use and the practicality of one remote makes it a worthwhile task.
If there is not a system listed that you want to control it has a neat feature which allow you to add other 'unknown' remote signals - its so easy - you just tell it you're going to add an 'unknown' and then point the 'unknown' systems remote at the logitech remote and it asks you to press the buttons. Thats it. We had to do that with one of ours and it works brilliantly and wasn't hard to do.
The Only Flaw to this remote is it can't control FM signalled devices such as motorised projector screens or bluetooth controlled devices such as Playstations - HOWEVER these devices can come with infra-red or infra-red can be bought as an accessory
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